Hemp and cannabinoids advanced research

Cannabis naturally produces hundreds of natural compounds that belong to families such as cannabinoids, terpenes, flavonoids and lipids.

Within the cannabinoid family, there are three categories:

  • Phytocannabinoids, which are organic substances produced exclusively by plants. They have the power to act as neurotransmitters by stimulating certain receptors in the human body.
  • Endocannabinoids which are molecules produced by the human body following a stimulus such as inflammation, stress or pain. They act locally and are rapidly broken down after their action.
  • Synthetic cannabinoids which are developed in laboratories. They are an exact replica of the natural molecules produced by plants.

Phytocannabinoids, which are present in large quantities in cannabis, are found in nettles and hops, close relatives of cannabis, but also in other more distant species such as rosemary. They are also found in certain mushrooms such as black truffles and cocoa beans.
Cannabis is so special because of its 600 compounds. Indeed, with more than 120 cannabinoids present in large quantities, it is the plant of choice for extracting the three main ones – CBD, CBN and CBG. These three cannabinoids are able to naturally activate the body’s receptors and act on the endocannabinoid system that is currently disrupting medicine.

For thousands of years, humans have cultivated and used cannabis for its rich compounds.

Originating in Central Asia, the oldest traces of its domestication date back to 12,000 BC. Even then, the plant was used for its high cannabinoid content, as well as for the strength of its fibres and the high protein content of its seeds.

The ECS or endocannabinoid system is currently the subject of numerous scientific studies, as the discoveries about it are immense.

In fact, the ECS allows us to maintain the balance of our body, i.e. the pH
Present in the nervous system, skin, organs, muscles and bones, this system maintains our homeostasis, i.e. the acid-base balance of our body.
In response to an imbalance such as inflammation or pain, the ECS will interact through CB1 and CB2 receptors on the surface of cells to secrete specific proteins that can calm us down and restore our homeostasis.

Human Endocannabinoid System horizontal textbook infographic illustration about cannabis as herbal alternative medicine and chemical therapy, healthcare and medical science vector.

Our skincare products are designed to use the full power of cannabinoids on our skin.

Thus, we mainly use CBD and CBG for their many properties that are scientifically proven to date:

  • Helps to calm pain and muscle spasms by acting directly on the cannabinoid receptors in the brain. Similar to neurotransmitters, when stimulated by taking cannabis, they produce a response in the body that calms pain and inflammation. Thus, you can use it to relieve muscle and joint pain.
  • They ease pain and reduce skin problems. In response to inflammation, such as irritation, acne, sunburn, cannabinoids will naturally help the body relieve pain and calm inflammation.

To go further, here are the latest scientific advances concerning the therapeutic properties of cannabinoids, CBD and CBG.


The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
PubMed National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. PMID: 28182367

Discovery of the endogenous cannabinoid system and how this system benefitted as well as unintentionally harmed human health
PubMed “Schurman LD, Lu D, Kendall DA, Howlett AC, Lichtman AH” Molecular Mechanism and Cannabinoid Pharmacology. Handb Exp Pharmacol. 2020;258:323-353. doi: 10.1007/164_2019_298. PMID: 32236882; PMCID: PMC8637936.

Cannabinoids and Potential Therapeutic Uses
PubMed “Walsh KB, McKinney AE, Holmes AE” Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses. Front Pharmacol. 2021 Nov 29;12:777804. doi: 10.3389/fphar.2021.777804. PMID: 34916950; PMCID: PMC8669157.

Cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions
PubMed “Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F.” Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018 Sep 27;23(10):2478. doi: 10.3390/molecules23102478. PMID: 30262735; PMCID: PMC6222489.

The therapeutic potential of cannabinoids remains an important topic for future investigations
PubMed “Walker JM, Strangman NM, Huang SM. Cannabinoids and pain”. Pain Res Manag. 2001 Summer;6(2):74-9. doi: 10.1155/2001/413641. PMID: 11854769.


Therapeutic Efficacy of Cannabidiol (CBD)
PubMed “Sholler DJ, Schoene L, Spindle TR” Therapeutic Efficacy of Cannabidiol (CBD): A Review of the Evidence from Clinical Trials and Human Laboratory Studies. Curr Addict Rep. 2020 Sep;7(3):405-412. doi: 10.1007/s40429-020-00326-8. Epub 2020 Jul 25. PMID: 33585159; PMCID: PMC7880228.

The effects of CBD in the broad area of inflammation
PubMed “Burstein S.” Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorg Med Chem. 2015 Apr 1;23(7):1377-85. doi: 10.1016/j.bmc.2015.01.059. Epub 2015 Feb 7. PMID: 25703248.

Cannabidiol and Sports Performance
“McCartney D, Benson MJ, Desbrow B, Irwin C, Suraev A, McGregor IS” Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research. Sports Med Open. 2020 Jul 6;6(1):27. doi: 10.1186/s40798-020-00251-0. PMID: 32632671; PMCID: PMC7338332.


The Pharmacological Case for Cannabigerol (CBG)
PubMed “Nachnani R, Raup-Konsavage WM, Vrana KE” The Pharmacological Case for Cannabigerol. J Pharmacol Exp Ther. 2021 Feb;376(2):204-212. doi: 10.1124/jpet.120.000340. Epub 2020 Nov 9. PMID: 33168643.

The anti-inflammatory effects of cannabidiol CBD and cannabigerol CBG alone, and in combination CBD+CBG
PubMed “Robaina Cabrera CL, Keir-Rudman S, Horniman N, Clarkson N, Page C” The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination. Pulm Pharmacol Ther. 2021 Aug;69:102047. doi: 10.1016/j.pupt.2021.102047. Epub 2021 Jun 1. PMID: 34082108.


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